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Non-monotonicity of BPA
In their presentation, the scientists provide background on CLARITY-BPA, the setup of their mammary gland study, and a detailed discussion of the analytical and statistical methods applied. They explain that their study shows clear statistical evidence of non-monotonic dose-response curves (NMDRC) of developmental exposure to BPA for multiple measurements, that such responses occurred at all ages of the animals studied, and argue that additional “mechanistic studies are not needed to accept that a NMDRC reflects a causal link to the exposure when the statistical methods of analysis are pertinent and rigorous.”
