Scholars used Aristotelian reasoning in combination with theology to understand living beings, leading to natural theology, where god was the guarantee of biological norms. Transformism, notably Darwin, provided an alternative to this view; however, this alternative had to be acknowledged by scientists when the model of science was classical mechanics. It followed that thinking about biological objects remained similar to physics thinking, where norms are laws, or at least invariants and symmetries. The recurring analogies with technological objects, recently computers, as viewed by engineers (and not users or anthropology) also contributed to this theoretical and epistemological bias and confusion. On the opposite, we can think about biological objects differently, on renewed theoretical bases, by starting from theoretical principles that are sound in this field. Then, instead of fast analogies, numerous new questions, methods, and reasoning have to be fleshed out.