Talks in english

  1. Disruptions: A specific kind of disorganization

    Biologists often use the term disruption more or less informally; however, this notion is increasingly used to describe the effects of detrimental anthropogenic causes. We argue that disruptions are distinct from perturbations or, in ecology, from generic disturbances. We illustrate this with examples from ecology using the case of plant-pollinator networks and organismal biology with endocrine disruptors. Specifically, we argue that understanding disruptions requires the articulation of historical and relational reasoning. The object of disruption, such as endocrine regulation or seasonal synchrony between plants and pollinators, is a specific property coming from history that is disturbed in a new way, leading to a loss or degradation of this specificity. Moreover, initially, this specificity plays a specific relational role, typically a functional one. This role is lost or impaired by the disruption which explains the disorganization characteristic of disruptions. In our view, however, disruptions are normal processes in evolution. What is severely detrimental is the current accumulation of disruptions at a pace that exceeds living entities' ability to overcome them.

  2. Concepts and principles for the new biology: Development, disruption and normalization

    During the first 25 years of the 21st century, we witnessed a resurgence of Organicism. This process is characterized by the return of the organism as a central biological entity and the increasing investigation on purpose and normativity at this level.</br> Simultaneously, the issue of the vulnerabilities of living beings and their numerous disruptions is escalating in urgency. The need to comprehend these disruptions, and how living beings adapt to them, is pressing. Organicism, with its systemic approach to disruptions and its focus on organisms’ normativity, is the most suitable framework for this understanding.</br> In this session, we will:</br> 1) explore the epistemological role played by the morphogenetic field concept in the studies on the etiology of tumors in the early 20th century and its resurgence in the organicist conception of cancer as development gone awry (presented by Claudia Gadaleta, Paris 1 Sorbonne Panthéon - IHPST, Paris, France),</br> 2) argue that a properly fleshed-out concept of disruption describes the effects of a significant category of detrimental anthropogenic causes in organisms and ecosystems. Understanding disruptions requires articulating historical and relational reasoning, which is a hallmark of recent theoretical developments (presented by Maël Montévil, Centre Cavaillès, Ecole Normale Supérieure, Paris, France)</br> 3) argue that disruption causes a loss of function. The organismal agency may overcome disruption by acquiring novel functions, a process we call normalization. We will discuss two examples: i) how young quadrupeds that lost the function of their forelimbs teach themselves to walk as bipeds, and ii) cancer, a disease usually perceived as irreversible but known to regress spontaneously by normalization (presented by Ana Soto, Tufts University, USA and Centre Cavaillès, Ecole Normale Supérieure, Paris, France).

  5. Physiology and historicity: Re-entangling the biological, the ecological and the social

    • M Montévil
      .
    • en
    • Colloque “philosophy of health – rethinking organism, environment and metabolism”
    • Sorbonne Université Salle des Fresques, Escalier D Salle D306, Paris

    Depending on the theoretical and epistemological stance in biology, the relations between the biological and social change in nature. A reductionist stance, for example, genocentrism, focuses scientific investigations on a specific part of the organism - then, the social stands, at best and by definition, in the outskirts as far as biology is concerned. On the opposite, the perspective we are elaborating for reasons internal to biology considers biology at the crossroads of historical and relational epistemologies. The object's definition is never purely based on synchronic relations, like in physics. Instead, biological objects are historical and contextual. Cultural or social determinations can enter the biological picture, more or less strongly depending on specific situations. For example, taste is a phenomenon that involves specific biological structures (taste buds, olfactory receptors), and one may think that it is independent of society. Food pairing studies showed instead that the way to perform associations depends on the culture. Of course, historicity also means that other receptors can also creatively be recruited, which is the case with the capsaicin of chili pepper that triggers pain receptors.

  6. The closure of constraints in practices

    • M Montévil
      M Montévil
      &
      A Robert
      A Robert
      .
    • en
    • Salle de réunion du centre Cavaillès, ENS

    What understanding does the closure of constraints bring about a biological system in practices? Without discussing particular cases, one cannot answer this question. The goal of this workshop is to bring together and synthesize individual modeling experiences in physiology and ecology to establish perspectives of research collectively regarding organization in biology, sensu closure of constraints. This workshop is intended to a specialized audience. We encourage speakers to present models or modeling methods, and share critical reflections on their work and the difficulties encountered. Identifying achievements, open questions, perspectives, and experimental, conceptual or technical difficulties is the main goal of this meeting. Additionally to relatively short Q&A sessions, a general discussion will synthesize the main points raised during the day. This synthesis will be transcribed and shared with the participants after the workshop.

  9. What is politics?

    • M Montévil
      .
    • en
    • Salle des Actes, ENS, 45 rue d'Ulm

    Politics is the fight for freedom; freedom does not exist outside of the struggles for it. Freedom is neither transcendent infinite being nor is it an Idea. Since the object of politics is not an Idea, there is no universal form for politics. The péjoration of politics, “politics” as a culture of lies and manipulations for gaining power, presupposes a non-political ideality or an anti-political totality. When philosophy commences otherwise than its ethno-history through an other beginning of philosophy politics is already opening a collective anticipation of freedoms unknown. For that very reason, unknown dangers await our political future.

  15. Open historicity of life. Theory, epistemology, practice

    • M Chollat-Namy
      M Chollat-Namy
      ,
      M Montévil
      M Montévil
      &
      A Robert
      A Robert
      .
    • en
    • Salle Dussane, ENS

    In the last decade, the notion that new possibilities appear over time in biological phenomena has received renewed and growing attention. Kauffman approaches it as the adjacent possible, Sarti and Citti as heterogenesis, and Longo and Montévil as symmetry change and specific objects. Accordingly, there is a growing understanding that this notion is a significant shift and challenge in the way to do science. However, there has yet to be a systematic effort to bring together the different perspectives on this question in biology and in other fields confronted with it. In this conference, we intend to create bridges between the different perspectives that have been developed, mostly independently, on the question of changing possibility spaces in biology.

  16. Historicity and theory

    This Diverse Format Session will discuss some biological principles and notions that, we submit, should be integrated into the theoretical concepts of biology. Overall, these notions delineate an organism-centered biological science, by shifting the focus to the wholes rather than their parts. In particular, the session will examine how the adoption of these principles and notions fundamentally challenges the received view on biological explanation. <br> The first notion is purposiveness. There is recent literature suggesting that biological organization can be interpreted as self-determining, and thereby intrinsically purposive (Mossio & Bich, 2017). Accepting the intrinsic purposiveness notion implies accepting a circular determination between the parts and the whole and thus a challenge to a mechanistic explanation of biological organization. The second notion is variation. In some recent studies (Montévil et al., 2016), biological variation is understood in terms of the emergence of changes that cannot be prestated. As such, biological variation challenges the very possibility of generalized formal models in biology. The third notion (Soto et al, 2016), is the biological default state according to which cells constantly grow, change shape, proliferate, and move. Because of this default state, the explanation of biological phenomena involving motility and proliferation is reversed, to the extent that what is to be accounted for is their absence (quiescence). The fourth notion is agency, which designates the capacity of organisms to behave in interaction with the environment and other organisms in a purposeful, normative, and functional way. Among other things, the conception of organisms as agents radically modifies evolutionary explanations (Jäger, 2023), insofar as agents are not only the result of selective processes, but they also actively shape selective processes. <br> The session will consist of four short presentations (15 minutes each, maximum), followed by a discussion of 30 minutes at least, in which we will explore the capacity of these concepts to advance biological explanation, as well as their (deep) conceptual connections.

  17. Biology lies at an epistemological interface

    • M Montévil
      .
    • en
    • Sustainable interfaces for complex systems analysis and understanding – spacetime in the living systems and their integral development
    • Campus Bio-Medico, University of Rome, Rome, Italie.

  20. Architectonique théorique en biologie et applications

    Si la physique, notamment la mécanique classique, a largement été mobilisée comme modèle de la compréhension théorique de la nature, la biologie a dans une certaine mesure, réussi à s'en détacher avec la théorie de l'évolution, une théorie où l'historicité est première. Néanmoins, cette innovation épistémologique et méthodologique n'est pas miscible avec la méthode de théorisation physique et il s'ensuit une étrange cohabitation dont les enjeux sont rarement traités. Nous proposerons des directions pour repenser la théorisation en biologie en insistant sur le concept de nouveau possible. Nous montrerons aussi que ce travail permet de mieux comprendre des phénomènes biologiques cruciaux : la disruption des organisations biologique dans l'Anthropocène.

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