A Novel 3D Model to Study the Link Between Hormonal Exposure and Mammographic Density in Breast Cancer

Lower type 1 collagen concentration (0.5 mg/ml) increases elongation of structures compared to 1 mg/ml. Fibroblasts enhances elongation of structures in 1 mg/ml, but not 0.5 mg/ml. In 1 mg/ml collagen, elongated epithelial structures had lumen formation when co­‐cultured with fibroblasts. Hormones in co-­‐cultures of T47D + fibroblasts, significantly altered the phenotype in terms of elongation.