Toward a theory of organisms: Three founding principles in search of a useful integration
Progress in Biophysics and Molecular Biology
We articulate three principles for a theory of organisms proposed, namely: the default state the principle of variation and the principle of organization.
Abstract Organisms, be they uni- or multi-cellular, are agents capable of creating their own norms; they are continuously harmonizing their ability to create novelty and stability, that is, they combine plasticity with robustness. Here we articulate the three principles for a theory of organisms, namely: the default state of proliferation with variation and motility, the principle of variation and the principle of organization. These principles profoundly change both biological observables and their determination with respect to the theoretical framework of physical theories. This radical change opens up the possibility of anchoring mathematical modeling in biologically proper principles.
Keywords: Default state, Biological organization, Organizational closure, Variation, Individuation