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Contents tagged “theoretical biology”

There are 3 contents with the tag “theoretical biology”:

  1. Conceptual and theoretical specifications for accuracy in medicine

    Personalized Medicine in the Making: Philosophical Perspectives from Biology to Healthcare


    Technological developments in genomics and other -omics originated the idea that precise measurements would lead to better therapeutic strategies. However, precision does not entail accuracy. Scientific accuracy requires a theoretical framework to understand the meaning of measurements, the nature...

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    Abstract:

    Technological developments in genomics and other -omics originated the idea that precise measurements would lead to better therapeutic strategies. However, precision does not entail accuracy. Scientific accuracy requires a theoretical framework to understand the meaning of measurements, the nature of causal relationships, and potential intrinsic limitations of knowledge. For example, a precise measurement of initial positions in classical mechanics is useless without initial velocities; it is not an accurate measurement of the initial condition. Conceptual and theoretical accuracy is required for precision to lead to the progress of knowledge and rationality in action. In the search for accuracy in medicine, we first outline our results on a theory of organisms. Biology is distinct from physics and requires a specific epistemology. In particular, we develop the meaning of biological measurements and emphasize that variability and historicity are fundamental notions. However, medicine is not just biology; we articulate the historicity of biological norms that stems from evolution and the idea that patients and groups of patients generate new norms to overcome pathological situations. Patients then play an active role, in line with the philosophy of Georges Canguilhem. We argue that taking this dimension of medicine into account is critical for theoretical accuracy.

    Keywords: Normativity, Organization, Personalized Medicine, Technology, theoretical biology

    Citation:

    Montévil, Maël. n.d. “Conceptual and Theoretical Specifications for Accuracy in Medicine.” In Personalized Medicine in the Making: Philosophical Perspectives from Biology to Healthcare. Springer; Springer

  2. Which first principles for mathematical modelling in biology?

    Which first principles for mathematical modelling in biology?

    Rendiconti di Matematica e delle sue Applicazioni


    Like theoretical physics, theoretical biology is not just mathematical modeling. Instead, it should strive to find suitable first principles to frame experiments and models.

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    Abstract:

    Like theoretical physics, theoretical biology is not just mathematical modeling. Instead, theoretical biology should strive to find suitable first principles to ground the understanding of biological phenomena and ultimately frame biological experiments and mathematical models. First principles in physics are expressed in terms of symmetries and the associated conservations, on the one side, and optimization on the other side. In biology, we argue instead that a strong notion of variation is fundamental. This notion encompasses new possibilities and the historicity of biological phenomena. By contrast, the relative regularity of some aspects of biological organisms, which we call constraints, should be regarded as the consequence of a mutual stabilization of the parts of organisms. We exemplify several aspects of this framework with the modeling of allometric relationships. Our change of perspective leads to reconsider the meaning of measurements and the structure of the space of description.

    Keywords: Allometry, first principles, Historicity, invariants, theoretical biology, Variability

    Citation:
  3. The Inert vs. the Living State of Matter: Extended Criticality, Time Geometry, Anti-Entropy — an overview

    The Inert vs. the Living State of Matter: Extended Criticality, Time Geometry, Anti-Entropy — an overview

    Frontiers in Physiology


    The physical singularity of life phenomena is analyzed by a comparison with the theories of the inert and focus on criticality, time, and anti-entropy.

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    Abstract:

    The physical singularity of life phenomena is analyzed by means of comparison with the driving concepts of theories of the inert. We outline conceptual analogies, transferals of methodologies and theoretical instruments between physics and biology, in addition to indicating significant differences and sometimes logical dualities. In order to make biological phenomenalities intelligible, we introduce theoretical extensions to certain physical theories. In this synthetic paper, we summarize and propose a unified conceptual framework for the main conclusions drawn from work spanning a book and several articles, quoted throughout.

    Keywords: criticality, biological time, anti-entropy, theoretical biology, symmetry, allometry, incompleteness

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